If you’re in search of 2D framework in python then Cocos is for you. It is 2D framework and suitable for making games and graphical demos.
It is available for multiple platforms: linux, mac and windows. Python and pyglet is necessary on system before you start working with cocos2D.
You can have sprite based animation and can direct sprites on where to move, delete and perform some action etc.
Documentation is also well written. You can browse it online or you can download. There are 5 tutorial videos for the beginners as well as intermediate users.
For more information you can check here.